I have been using SkinMedica TNS Essential Serum for over five years. As a mature senior citizen woman, I have found this product helps to fully moisturize my facial tissue as well as maintain skin plumpness. As a result I am told I look years below my age. SkinMedica Serum is far superior to other moisturizing brands I have used in the past. I am lucky to have found this product and plan to continue to use it for years to come.