I to ordered front line plus and was told the combo was the same product and that is was all made in the UK reguardless of label. I have seen no bad skin reactions but after two monthly applications each on our four dogs they have several times more fleas than I've ever seen. The last treatment was two weeks ago and I ran a flea comb thru them last night and between them I removed more sixteen very alive fleas. The old saying if sounds to good to be true, never again, I was in the parking lot this morning waiting for my vet to open, dave in florida