You are never truly 'done', you are always going to refine the station. But, I agree with the other posters... it's possible to get up and running in a couple of hours, and then refinements will take additional time as you go along.

I just started using Radionomy a few days ago. I had my feed up and running in a couple of hours; however, it will take some time for you to our together a customized program for each day. At this point I am still building my programs and organizing songs, but my station is up and running with a little over 3 hours of music on heavy rotation.

Hard to say since I would not know what typical would be. My friend is still messing with hers so Ill let yo uknow when she is done. But something tells me that will never happen.