Hello Teresa--You can use the coupons more than once (as often as you're able to refill your prescription), and they don't expire. However, we always recommend that you check the coupon price on the website again before refilling so there won't be any surprises when you pick up your prescription. Because the coupon prices are tied to actual cash prices which fluctuate over time, prices can change from month to month. We do recommend printing a new coupon each time you fill or refill a prescription, and please be sure that the pharmacist enters the current coupon information, as we list coupons from several different coupon providers who each have separate discount rates. Checking our website before you go to the pharmacy and printing a new coupon, will allow you to receive the best price every time you fill or refill a prescription.