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on 5/12/16I have not tried Frontline, but I have used Sentinel, Heartgard and Revolution from here and have always been pleased with results.
Purchased Frontline Plus from the web site for my dogs... applied it 3 days ago. Today, I rolled my dog over to scratch his belly and a cascade of fleas was running all over him. I lost count in the thirties and immediately gave him a flea bath. My wife's ankles are raw. Does that answer your question?
Never had an issue, I just placed another order today.