The B12 with Intrinsic Factor is something that no one else has developed and is the only supplement that will keep the level of B12 up in an EPI dog. The disease taxes their B12 supply severely and it can be replaced by B12 shots or by these special B12 capsules. They may not act as quickly as the shots, but then the shots don't always work either. But, this capsule seems to be accepted by all EPI dogs. I'm grateful this company has researched and developed such a needful product for our fur babies.