There are many differences. Hydrogine does not create pure therapeutic hydrogen gas and dissolved hydrogen water is lesser. It is a much larger and bulkier machine as well. Please note that Hydrogenie makes a mixture of oxygen and other types of gases, and any hydrogen gas inhalation research results do not apply to Hydrogene because it is not pure hydrogen gas. Purity and level of the hydrogen is the most important thing when you choosing the device. Hydrogen has no side effects, but oxygen has negative side effects and needs to be used with caution. Japan has been the pioneer of the hydrogen research and they are many years ahead. Lourdes Hydrofix was developed by the top engineers and scientists who have been involved with hydrogen for the longest, and it is the latest technology from Japan. If you would like to know more, please contact our customer support and we can answer any questions you may have! Thank you.